Hennessy Research (West Nile Virus, Animal Vaccines) Hennessy Research
   
   
 
Quality Statement:

Hennessy Research is dedicated to providing competent scientific expertise toward development of safe, efficacious, cost-effective and innovative products for the animal health industry. We commit to unwavering service and support to our clients, and commit to the understanding and delivery of client requirements on an unsurpassed level of quality and timeliness.

 
History:

HRA is a growth-oriented Animal Health Research and Development company established by Kristina J. Hennessy, DVM, Ph.D., Diplomate, ACVM (Immunology) in 2000. Tenured scientists with over 200 years of combined experience form the framework for the Hennessy Research team. Since inception, HRA has provided quality services to local, national and international companies.

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Specialty Services:

HRA specializes in the Research and Development of vaccines for infectious diseases of animals. As a part of this specialization, HRA scientists are skilled in biological manufacturing processes, in vitro test development, lab animal and host animal challenge model development, and USDA ELISA Reference Requalification methods. These scientists work closely with client company scientists, technicians, and regulatory personnel to bring an optimized production process to the client’s manufacturing site.

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Credentials:
Kristina J. Hennessy, DVM, Ph.D.
Diplomate ACVM (Immunology)
Hennessy Research Associates. LLC
12700 Johnson Drive, Shawnee, KS 66216
913-268-5700  Hennessy@kc.rr.com
PROFESSIONAL EXPERIENCE
 

HENNESSY RESEARCH ASSOCIATES LLC - SHAWNEE, KS.          2001 to present

CEO/Chief Scientific Officer
Directly responsible for efficient operation of the company and its profitability, including implementing budgets, new program development, quality standards, policies and procedures. Directs marketing and sales to achieve company profit and growth goals. Provides scientific expertise and direction to a team of scientists responsible for professionally and efficiently performing contract R&D services in a manner suitable to client’s needs.

 

Intervet Inc. - Overland Park ,KS.          2000 — 2001

Group Leader – Equine Biological R&D
Supervised research, development and licensure of novel equine vaccines for the U.S. market. Also provided product support, registration, tech transfer and personnel training for all aspects of equine vaccines manufactured in the U.S. Recent vaccines licensed include Prestige V + VEE and Prestige V (equine herpesvirus 1&4, influenza A1 and A2, Eastern Equine Encephalomyelitis, Western Equine Encephalomyelitis, tetanus toxoid). Reported to the Director of Companion Animal R&D.

 

Bayer Corp., Animal Health.          1993 — 2000

Manager, Companion Animal Vaccine Development, Worldwide
Manager -Immunochemistry/Process Improvement
Directed scientific team responsible for small animal and equine vaccine development on a world wide basis. Worked closely with international consultants and regulatory authorities to assure compliance with EU regulations for equine vaccine registration. Involved in construction of new manufacturing facilities for GMP compliance. Also managed scientific team responsible for in-vitro test development and reference requalification (product maintenance). Responsibilities also included process improvement and trouble-shooting of vaccines at Bayer U.S. manufacturing sites.

 

Kansas State University College of Veterinary Medicine          1993 — Present
Adjunct Assistant Professor, Dept. of Pathology and Microbiology

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EDUCATION
 

UNIVERSITY OF MISSOURI – KANSAS CITY, B.A,. 1979

UNIVERSITY OF MISSOURI – KANSAS CITY, M.A., 1983

KANSAS STATE UNIVERSITY, MANHATTAN, KANSAS, D.V.M., 1987

KANSAS STATE UNIVERSITY, MANHATTAN, KANSAS, PH.D., 1990

AMERICAN COLLEGE OF VETERINARY MICROBIOLOGISTS

BOARD CERTIFICATION 1992, IMMUNOLOGY

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VACCINES REGISTERED
 

Feline Products
Feline Rhinotracheitis-Calici-Panleukopenia, KV, Code 16D5.20
Feline Leukemia Vaccine, KV, Code 1555.20

Equine Products
Equine Influenza Vaccine, KV, Code 1505.21
Equine Rhinopneumonitis-Influenza Vaccine, KV, Code 1515.21
Encephalomyelitis-Influenza Vaccine, Eastern and Western, KV, Tetanus Toxoid, Code 4835.44
Encephalomyelitis-Rhinopneumonitis-Influenza Vaccine, Eastern and Western, Killed Virus, Tetanus Toxoid, Code 4845.31
Encephalomyelitis Vaccine, Venezuelan, Eastern and Western, Killed Virus, Tetanus Toxoid, Code 4875.AO
Encephalomyelitis-Influenza Vaccine, Venezuelan, Eastern and Western, Killed Virus, Tetanus Toxoid, Code 4865.23
Encephalomyelitis-Rhinopneumonitis-Influenza Vaccine, Eastern, Western and Venezuelan, Killed Virus, Tetanus Toxoid, Code 4847.30

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ISSUED PATENTS
 

Feline Vaccines containing Chlamydia psittaci and method for making the same.
Inventors: R.Atherton, N. Schmeer, J. Hallstrom, J. Lane and K. Hennessy.
Patent No. 5,972,350. Date of Patent: Oct. 26, 1999.

EIAV p26 deletion vaccine and diagnostic.
Inventors: R. Montelaro, J. Craigo, C. Issel, B. Puffer, K.J. Hennessy and K.K. Brown. Patent No. 6,461,616. Date of Patent: Oct. 8, 2002.

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PATENT APPLICATIONS
 

An adjuvanted vaccine which is substantially free of non-host albumin.
Inventors: K. Hennessy, K. Brown, J. Lane and S. Trump.

3 patent applications dealing with equine vaccine development, host animal vaccination/challenge models and diagnostics.

Pharmaceutical Composition of Complex Carbohydrates and their Methods and Use. Inventors: H. Brown, K. Hennessy, C. Cooper and K. Brown. Published Aug. 1, 2000 PCT

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PUBLICATIONS
 
Flaminio, MJ, BR Rush, EG Davis, KJ Hennessy, W Shuman and MJ Wilkerson.
2000. Characterization of peripheral blood and pulmonary leukocyte function in healthy foals. Vet Immuno Immunopathol. 73(3-4):267-285.
Redhead, K, R Lucken, A van de Moer, S Houghton, B Simpson, A Cameron,
P Monkton, K Hennessy and C. Ellis. 1999. Veterinary Vaccines: In-VITRO-International Veterinary Industry Test Replacement Organisation. In: Brown, F, C Hendriksen and D Sesardic (eds): Alternatives to Animals in the Development and Control of Biological Products for Human and Veterinary Use. Dev Biol Stand. Basel, Karger, vol 101, pp261-266.
Hennessy, KJ, JJ Iandolo and BW Fenwick. 1993. Serotype identification
of Actinobacillus pleuropneumoniae by arbitrarily-primed polymerase chain reaction. J. Clin. Microbiol. 31(5):1155-1159.
Briggs, DJ, KJ Hennessy, GA Kennedy and MJ Dean. 1992. Rabies in a
vaccinated canine exhibiting generalized demodicosis. J. Vet. Diagn. Invest. 5(2):248-249.
Oberst, RD, MP Hays, KJ Hennessy, LC Stine, JF Evermann and CL Kelling.
1993. Identifying bovine respiratory syncytial virus by reverse transcription-polymerase chain reaction and oligonucleotide hybridizations. J. Clin. Microbiol. 31(5):1237-1240.
Stone, GG, MM Chengappa, RD Oberst, NH Gabbert, S McVey, KJ Hennessy, M
Muezenberger and J Staats. 1993. Application of polymerase chain reaction for the correlation of Salmonella serovars recovered from greyhound feces to their diet. J. Vet. Diagn. Invest. 5(3):378-385.
Frank, RK, MM Chengappa, RD Oberst, KJ Hennessy, SC Henry and BW
Fenwick. 1992. Pleuropneumonia caused by Actinobacillus pleuropneumoniae biotype 2 in growing and finishing pigs. J. Vet. Diagn. Invest. 4:270-278.
Hennessy, KJ, S Arkins, KW Kelley, JE Minton, W Xue, HC Minocha and F
Blecha. 1992. Virus-infected bovine lymphocytes express the gene for pro-opiomelanocortin, but ACTH is not translated. J. Leuk.Biol. (in preparation)
Hennessy, KJ, F Blecha, BW Fenwick, RC Thaler and JL Nelssen. 1990.
Human recombinant interleukin-2 augments porcine natural killer cell cytotoxicity in vivo. Ann. Rech. Vet. 21:101-109.
Hennessy, KJ, F Blecha, DS Pollmann, EF Kluber III. 1987. Isoprinosine
and levamisole immunomodulation in artificially reared neonatal pigs. Am. J. Vet. Res. 48(3):477-480.
Jeon, IJ, SJ Galitzer, and KJ Hennessy. 1984. Rapid determination of
lactose and its hydrolyzates in whey and whey permeate by high performance liquid chromatography. J. Dairy Sci. 67:884-887.
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ABSTRACTS/POSTER PRESENTATIONS
 
Flaminio, MJBF, BR Rush, EG Davis, KJ Hennessy, W Shuman and MJ
Wilkerson. 1998. Simultaneous quantification of phagocytosis and oxidative burst activity of polymorphonuclear leukocytes in horses. Phi Zeta, Kansas State University.
Flaminio, MJBF, BR Rush, EG Davis, KJ Hennessy, W Shuman and MJ
Wilkerson. 1998. Quantification of phagocytosis and oxidative burst activity of polymorphonuclear leukocytes in healthy foals. Phi Zeta, Kansas State University.
Hennessy, KJ, B Moore, L Choromanski, D Ciszewski and GP Shibley. 1994.
Effectsof the Immunostimulant Baypamun on the Clinical and Immunologic Response of Dogs and Horses to Viral Challenge. The 13th International Symposium of the World Association of Veterinary Microbiologists, Immunologists, and Specialists in Infectious Diseases. Perugia, Mantova, Italy.
Stone, GG, MM Chengappa, N Gabbert, J Staats, M Meunzenberger and KJ Hennessy.
1992. Application of PCR for the correlation of Salmonella serovars recovered from greyhound feces to their diet. AAVLD Meeting, Lexington, Kentucky.
Briggs, DJ, KJ Hennessy, GA Kennedy and MJ Dean. 1992. Rabies in a
vaccinated canine exhibiting generalized demodicosis. AAVLD Meeting, Lexington, Kentucky.
Stone, GG, MM Chengappa, RD Oberst, KJ Hennessy, and J Staats. 1992.
Application of the PCR technique for the correlation of Salmonella serovars recovered from greyhound feces to their diet. Missouri Valley ASM Meeting, Lawrence, Kansas.
Fenwick, BW and KJ Hennessy. 1991. Porcine respiratory disease. 53rd
Annual Conference for Veterinarians. Kansas State University, Manhattan, Kansas.
Hennessy, KJ and BW Fenwick. 1991. Genomic fingerprinting of Actinobacillus
pleuropneumoniae using arbitrarily primed polymerase chain reaction. Conf. Res. Workers Anim. Dis. Chicago, Illinois.
Hennessy, KJ, JJ Iandolo and BW Fenwick, 1990. Identification of
infection-dependent antigens of Actinobacillus pleuropneumoniae. CRWAD. Chicago, Illinois.
Reddy, DN, HC Minocha, PG Reddy, KJ Hennessy, and F Blecha. 1990.
Isolation and characterization of monoclonal antibodies specific for recombinant bovine interleukin-2 (rbo IL-2). CRWAD. Chicago, Illinois.
Reddy, DN, KJ Hennessy, CG Chitko-McKown, PG Reddy, HC Minocha and F
Blecha. 1990. Isolation and characterization of monoclonal antibodies to bovine interleukin-1. FASEB. New Orleans, Louisiana.
Blecha, F, PG Reddy, HC Minocha, BW Fenwick, PE Baker, KJ Hennessy, DN
Reddy and GA Anderson. 1989. In vivo use of interleukin-1 and interleukin-2 in cattle and pigs. Immunobiology (suppl. 4):155. Presented at the second International Veterinary Immunology Symposium, Hannover, Germany.
Polam, S, F Blecha, KJ Hennessy and D Atluru. 1988. Regulation of bovine
mononuclear cell proliferation by the protein kinase inhibitor, H-7. Proceedings of the Ninth European Immunology Meeting, p. 364. Rome, Italy.
Hennessy, KJ, F Blecha, BW Fenwick, RC Thaler and JL Nelssen. 1988. In
vivo interleuken-2 treatment increases porcine natural cytotoxicity. FASEB J. 2:A1473.
Hennessy, KJ, F Blecha, EF Kluber III and DS Pollmann. 1985.
Immunomodulation in artificially reared neonatal pigs. Agricultural Experiment Station Conference, Manhattan, Kansas.
Blecha, F, KJ Hennessy, DS Pollmann and EF Kluber III. 1985. Methods to
overcome disease susceptibility in neonatal pigs. American Pork Congress, Indianapolis, Indiana.
Hennessy, KJ, F Blecha, EF Kluber III and DS Pollmann. 1985.
Isoprinosine and levamisole increase lymphocyte proliferative responses in artificially reared neonatal pigs. Proceedings 2nd International Conference on Effector Mechanisms in Domestic Animals, College Station, Texas.
Hennessy, KJ, F Blecha, DS Pollmann and EF Kluber. 1985.
Immunomodulation in artificially reared neonatal pigs. J. Anim. Sci. 61 (Suppl. 1):240. National ASAS Annual Meeting, Athens, Georgia.
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